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Chlordiazepoxide
Chlordiazepoxide (Librium)
Chlordiazepoxide
(klor-dye-AYZ-eh-POX-eyed)
Pregnancy Category: D
Apo-Chlordiazepoxide
Corax
Libritabs
Librium
Lipoxide
Mitran
Novo-Poxide
Reposans-10
(C-IV) (Rx)
Classification:
Antianxiety agent, benzodiazepine
See Also:
See also Tranquilizers, Antimanic Drugs, and Hypnotics[.
]Action/Kinetics:
Onset: PO, 30-60 min; IM, 15-30 min (absorption may be slow and erratic); IV, 3-30 min. Peak plasma levels (PO): 0.5-4 hr. Duration: t1/2: 5-30 hr. Is metabolized to four active metabolites: desmethylchlordiazepoxide, desmethyldiazepam, oxazepam, and demoxepam. Has less anticonvulsant activity and is less potent than diazepam.
Uses:
Anxiety, acute withdrawal symptoms in chronic alcoholics. Sedative-hypnotic. Preoperatively to reduce anxiety and tension. Tension headache. Antitremor agent (PO). Antipanic (parenteral).
Additional Side Effects:
Jaundice, acute hepatic necrosis, hepatic dysfunction.
Laboratory Test Alterations:
 17-Hydroxycorticosteroids, 17-ketosteroids, alkaline phosphatase, bilirubin, serum transaminase, porphobilinogen.  PT (clients on Coumarin).
How Supplied:
Capsule: 5 mg, 10 mg, 25 mg; Powder for injection: 100 mg
Dosage
•Capsules, Tablets
Anxiety and tension.
Adults: 5-10 mg t.i.d.-q.i.d. (up to 20-25 mg t.i.d.-q.i.d. in severe cases). Reduce dose to 5 mg b.i.d.-q.i.d. in geriatric or debilitated clients. Pediatric, over 6 years, initial, 5 mg b.i.d.-q.i.d. May be increased to 10 mg b.i.d.-q.i.d.
Preoperatively.
Adults: 5-10 mg t.i.d.-q.i.d. on day before surgery.
Alcohol withdrawal/sedative-hypnotic.
Adults: 50-100 mg; may be increased to 300 mg/day; then, reduce to maintenance levels.
•IM, IV (not recommended for children under 12 years)
Acute/severe agitation, anxiety.
Initial: 50-100 mg; then, 25-50 mg t.i.d.-q.i.d.
Preoperatively.
Adults: 50-100 mg IM 1 hr before surgery.
Alcohol withdrawal.
Adults: 50-100 mg IM or IV; repeat in 2-4 hr if necessary. Dosage should not exceed 300 mg/day.
Antipanic.
Adults, initial: 50-100 mg; dose may be repeated in 4-6 hr if needed. |
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