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Butoconazole nitrate
Butoconazole nitrate (Femstat)
Butoconazole nitrate
(byou-toe-KON-ah-zohl)
Pregnancy Category: C
Femstat 1 (Rx)
Femstat 3 (OTC)
Classification:
Antifungal agent
Action/Kinetics:
By permeating chitin in the fungal cell wall, butoconazole increases membrane permeability to intracellular substances, leading to reduced osmotic resistance and viability of the fungus. Approximately 5.5% of drug is absorbed following vaginal administration; plasma. t1/2: 21-24 hr.
Uses:
Vulvovaginal fungal infections caused by Candida species.
Contraindications:
Use during first trimester of pregnancy.
Special Concerns:
Pediatric dosage has not been established. Use with caution during lactation.
Side Effects:
GU: Vaginal burning, vulvar burning or itching, discharge; soreness, swelling, and itching of the fingers.
How Supplied:
Vaginal cream: 2%
Dosage
•Vaginal Cream (2%)
During pregnancy, second and third trimesters only.
One full applicator (about 5 g) of the cream intravaginally at bedtime for 6 days.
Nonpregnant.
One full applicator (about 5 g) intravaginally at bedtime for 3 days (if necessary, may be used for up to 6 days). NOTE: Vaginal infections may also be treated by one dose of butoconazole. |
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