| Aurothioglucose
Aurothioglucose (Solganol)
Aurothioglucose
(or-oh-thigh-oh-GLOO-kohz)
Pregnancy Category: C Solganol
(Rx)
Classification: Antiarthritic
See Also: For additional
information regarding aurothioglucose, see Gold Sodium Thiomalate [. ]
Action/Kinetics: The gold
content of aurothioglucose is 50%. Time to peak effect: 4-6 hr. Mean
steady-state plasma levels: 1-6 mc/mL. Is 95%-99% protein bound. t1/2,
after 11th dose: Up to 168 days. Seventy percent is excreted in the urine and 30% is
excreted through the urine.
Side Effects: GI:
N&V, anorexia, abdominal cramps, metallic taste, gastritis, ulcerative
enterocolitis colitis. Dermatologic: Dermatitis (papular, vesicular,
exfoliative), rash, urticaria, angioedema, chrysiasis. Renal: Nephrotic syndrome,
glomerulonephritis with proteinuria and hematuria, acute renal failure secondary to acute
tubular necrosis, acute nephritis, degeneration of proximal tubular epithelium. Hematologic:
Granulocytopenia, panmyelopathy, hemorrhagic diathesis. Respiratory:
Inflammation of upper respiratory tract, pharyngitis, tracheitis, bold bronchitis,
interstitial pneumonitis, fibrosis. CNS: Confusion, hallucinations, seizures.
Mucous membranes: Stomatitis, diffuse glossitis, gingivitis. Reactions of the
nitroid type: Anaphylactoid symptoms, flushing, fainting, dizziness, sweating,
N&V, malaise, headache, weakness. Ophthalmologic: Iritis, corneal ulcers, gold
deposits in ocular tissues. Miscellaneous: Vaginitis.
Overdose Mangement: Treatment:
Discontinue and give dimercaprol. Provide supportive therapy for renal and hematologic
symptoms. In acute overdose, induce emesis or gastric lavage immediately.
How Supplied: Injection:
50 mg/mL
Dosage
•IM Only Rheumatoid arthritis.
Adults: Week 1: 10 mg; weeks 2 and 3: 25 mg; then, 25-50
(maximum) mg/week until a total of 0.8-1 g has been administered. If client tolerates the
dose and has improved, 50 mg may be given q 3-4 weeks for several months. Pediatric,
6-12 years: Week 1: 2.5 mg; weeks 2 and 3: 6.25 mg; then, 12.5
mg/week until a total dose of 200-250 mg has been administered. Maintenance: 6.25-12.5
mg q 3-4 weeks. |
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