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Ampicillin oral
Ampicillin oral (Omnipen, Polycillin, Principen)
Ampicillin
(am-pih-SILL-in)
Pregnancy Category: B Jaa Amp Marcillin Novo-Ampicillin Omnipen Penbritin Principen Totacillin (Rx)
NOTE:The following Canadian drugs are ampicillin trihydrate: Apo-Ampi, Jaa Amp, Nu-Ampi, Pro-Ampi, Taro-Ampicillin.
Ampicillin with Probenecid
Ampicillin with Probenecid
Ampicillin with Probenecid
(am-pih-SILL-in, proh-BEN-ih-sid) Pro-Biosan (Rx)
Ampicillin sodium, parenteral
Ampicillin sodium, parenteral (Omnipen-N, Polycillin-N, Totacillin-N)
Ampicillin sodium, parenteral
(am-pih-SILL-in)
Pregnancy Category: B Ampicin Omnipen-N (Rx)

Classification: Antibiotic, penicillin

See Also: See also Anti-Infectives and Penicillins.

Content: The Powder for Oral Suspension of Ampicillin with Probenecid contains 3.5 g ampicillin and 1 g probenecid per bottle.

Action/Kinetics: Synthetic, broad-spectrum antibiotic suitable for gram-negative bacteria. Acid resistant, destroyed by penicillinase. Absorbed more slowly than other penicillins. From 30% to 60% of PO dose absorbed from GI tract. Peak serum levels: PO: 1.8-2.9 mcg/mL after 2 hr; IM, 4.5-7 mcg/mL. t1/2: 80 min--range 50-110 min. Partially inactivated in liver; 25%-85% excreted unchanged in urine.

Uses: Infections of respiratory, GI, and GU tracts caused by Shigella, Salmonella, Escherichia coli, Hemophilus influenzae, Proteus strains, Neisseria gonorrhoeae, N. meningitidis and Enterococcus. Also, otitis media in children, bronchitis, rat-bite fever, and whooping cough. Penicillin G-sensitive staphylococci, streptococci, pneumococci.

Additional Drug Interactions: Allopurinol / Skin rashes Oral contraceptives/ Effect of ampicillin

How Supplied: Ampicillin oral: Capsule: 250 mg, 500 mg; Powder for reconstitution: 125 mg/5 mL, 250 mg/5 mL. Ampicillin with Probenecid: See Content. Ampicillin sodium parenteral: Powder for injection: 125 mg, 250 mg, 500 mg, 1 g, 2 g, 10 g

Dosage
•Ampicillin: Capsules, Oral Suspension; Ampicillin Sodium: IV, IM Respiratory tract and soft tissue infections.
PO: 20 kg or more: 250 mg q 6 hr; less than 20 kg: 50 mg/kg/day in equally divided doses q 6-8 hr. IV, IM: 40 kg or more: 250-500 mg q 6 hr; less than 40 kg: 25-50 mg/kg/day in equally divided doses q 6-8 hr.
Bacterial meningitis.
Adults and children: 150-200 mg/kg/day in divided doses q 3 to 4 hr. Initially give IV drip, followed by IM q 3 to 4 hr.
Bacterial endocarditis prophylaxis (dental, oral, or upper respiratory tract procedures).
Clients at moderate risk or those unable to take PO medications: Adults, IM, IV: 2 g 30 min prior to procedure; children: 50 mg/kg, 30 min prior to procedure. Clients at high risk: Adults, IM, IV: 2 g ampicillin plus gentamicin, 1.5 mg/kg, given 30 min before procedure followed in 6 hr by ampicillin, 1 g IM or IV, or amoxicillin, 1 g PO. Children, IM, IV: Ampicillin, 50 mg/kg, plus gentamicin, 1.5 mg/kg, 30 min prior to procedure followed in 6 hr by ampicillin, 25 mg/kg IM or IV, or amoxicillin, 25 mg/kg PO.
Septicemia.
Adults/children: 150-200 mg/kg/day, IV for first 3 days, then IM q 3-4 hr.
GI and GU infections, other than N. gonorrhea.
Adults/children, more than 20 kg: 500 mg PO q 6 hr. Use larger doses, if needed, for severe or chronic infections. Children, less than 20 kg: 100 mg/kg/day q 6 hr.
N. gonorrhea infections.
PO: Single dose of 3.5 g given together with probenecid, 1 g. Parenteral, Adults/children over 40 kg: 500 mg IV or IM q 6 hr. Children, less than 40 kg: 50 mg/kg/day IV or IM in equally divided doses q 6 to 8 hr.
Urethritis in males caused by N. gonorrhea.
Parenteral, males over 40 kg: Two 500 mg doses IV or IM at an interval of 8 to 12 hr. Repeat treatment if necessary. In complicated gonorrheal urethritis, prolonged and intensive therapy is recommended.
•Ampicillin with Probenecid: Oral Suspension
Urethral, endocervical, or rectal infections due to N. gonorrhoeae.

Adults: 3.5 g ampicillin and 1 g probenecid as a single dose.
Prophylaxis of infection in rape victims.
3.5 g with 1 g probenecid.