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Altretamine
(Hexylmethyl-melamine)
Altretamine (Hexalen)
Hexylmethylmelamine (Hexalen)
Altretamine
(all-TRET-ah-meen)
Pregnancy Category: D
Hexalen (Rx)
Classification:
Antineoplastic, miscellaneous
See Also:
See also Antineoplastic Agents.
Action/Kinetics:
The mechanism of action is unknown, although metabolism of the drug is required for cytotoxicity. Well absorbed following PO ingestion; undergoes rapid demethylation in the liver, yielding the principal metabolites-pentamethylmelamine and tetramethylmelamine. Peak plasma levels: 0.5-3 hr. t1/2: 4.7-10.2 hr. Metabolites are excreted mainly through the kidney.
Uses:
Used alone in the palliative treatment of persistent or recurrent ovarian cancer after first-line cisplatin- or alkylating agent-based combination therapy.
Contraindications:
Preexisting bone marrow depression or severe neurologic toxicity, although the drug has been used safely in clients with preexisting cisplatin neuropathies. Lactation.
Special Concerns:
Safety and effectiveness have not been determined in children. High daily doses may result in gradual onset of N&V.;
Side Effects:
GI: N&V; (most common). Neurologic: Peripheral sensory neuropathy, fatigue, anorexia, seizures. CNS: Mood disorders, disorders of consciousness, ataxia, dizziness, vertigo. Hematologic: Leukopenia, thrombocytopenia, anemia. Miscellaneous: Hepatic toxicity skin rash, pruritus, alopecia.
Laboratory Test Alterations:
 Serum creatinine, BUN, alkaline phosphatase.
Drug Interactions:
Use with MAO inhibitors may cause severe orthostatic hypotension, especially in clients over the age of 60 years.
How Supplied:
Capsule: 50 mg
Dosage
•Capsules
Ovarian cancer.
260 mg/m2/day given either for 14 or 21 consecutive days in a 28-day cycle. The total daily dose is given as four divided doses PO after meals and at bedtime. |
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