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Alpha-1-Proteinase Inhibitor (Human)
(Alpha-1-PI)
Alpha-1-Proteinase Inhibitor (Human) (Prolastin)
Alpha-1-PI (Prolastin)
Alpha-1-Proteinase inhibitor
(AL-fah-1-PROH-tee-in-ayz)
Pregnancy Category: C
Prolastin (Rx)
Classification:
Alpha-1-proteinase inhibitor
Action/Kinetics:
Alpha-1-PI is the enzyme that is deficient in alpha-1-antitrypsin disease. This disease causes a progressive breakdown of elastin tissues in the alveoli, resulting in emphysema. Often fatal, alpha-1-antitrypsin disease is usually manifested in the third and fourth decades of life. Prolastin is a sterile, lyophilized product obtained from pooled human plasma that is nonreactive for the HIV antibody and the hepatitis B surface antigen. t1/2: 4.5 days. Therapeutic serum levels: Approximately 80 mg/dL, although such levels may not reflect actual functional alpha-1-PI levels.
Uses:
Panacinar emphysema due to congenital alpha-1-proteinase deficiency.
Contraindications:
Clients with PiMZ or PiMS phenotypes of alpha-1-antitrypsin deficiency.
Special Concerns:
Use with caution in clients at risk for circulatory overload. Safety and efficacy for use in children not determined.
Side Effects:
Although precautions are taken during the manufacture of this product, it is possible that hepatitis and other infectious viruses may be present. Miscellaneous: Delayed fever up to 12 hr following treatment, dizziness, lightheadedness, mild transient leukocytosis.
How Supplied:
Powder for injection: 20 mg/mL after reconstitution
Dosage
•IV Only
Panacinar emphysema.
Adults: 60 mg/kg each week at a rate of 0.08 mL/kg/min (or greater). |
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