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Meclizine hydrochloride
Meclizine hydrochloride (Antivert)
Meclizine hydrochloride
(MEK-lih-zeen)
Pregnancy Category: B Antivert Antivert/25 and /50 Antivert/25 Chewable Antrizine Bonamine Bonine Dizmiss Dramamine II Meni-D Ru-Vert-M (OTC and Rx)

Classification: Antihistamine (piperidine-type), antiemetic, antimotion sickness

See Also: See also Antihistamines and Antiemetics.

Action/Kinetics: Mechanism for the antiemetic effect may be due to a central anticholinergic effect to decrease vestibular stimulation and depress labyrinthine activity. May also act on the CTZ to decrease vomiting. Onset: 30-60 min; Duration: 8-24 hr. t1/2: 6 hr.

Uses: Nausea and vomiting, dizziness of motion sickness, vertigo associated with diseases of the vestibular system.

Special Concerns: Safety for use during lactation and in children less than 12 years of age has not been determined. Pediatric and geriatric clients may be more sensitive to the anticholinergic effects of meclizine.

Side Effects: CNS: Drowsiness, excitation, nervousness, restlessness, insomnia, euphoria, vertigo, hallucinations (auditory or visual). GI: N&V;, diarrhea, constipation, anorexia. GU: Urinary frequency or retention; difficulty in urination. CV: Hypotension, tachycardia, palpitations. Miscellaneous: Dry nose and throat, blurred or double vision, tinnitus, rash, urticaria.

How Supplied: Capsule: 25 mg; Chew Tablet: 25 mg; Tablet: 12.5 mg, 25 mg, 30 mg, 50 mg

Dosage
•Capsules, Tablets, Chewable Tablets Motion sickness.
Adults: 25-50 mg 1 hr before travel; may be repeated q 24 hr during travel.
Vertigo.
Adults: 25-100 mg/day in divided doses.